Inhibition of Mitogen-activated Protein Kinase Kinase Induces Apoptosis of Human Chondrocytes
نویسندگان
چکیده
منابع مشابه
Inhibition of mitogen-activated protein kinase kinase induces apoptosis of human chondrocytes.
We previously have reported that the mitogen-activated protein kinase (MAPK) pathway is stimulated by adhesion of human chondrocytes to anti-beta(1)-integrin antibodies or collagen type II in vitro. These mechanisms most likely prevent chondrocyte dedifferentiation to fibroblast-like cells and chondrocyte death. To investigate whether this pathway plays an essential role for the differentiation...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m010859200